Blood donation campsA blood donation occurs when a person voluntarily has blood drawn and used for transfusions and/or made into biopharmaceutical medications by a process called fractionation (separation of whole-blood components). Donation may be of whole blood (WB), or of specific components directly (the latter called apheresis). Blood banks often participate in the collection process as well as the procedures that follow it.


Today in the developed world, most blood donors are unpaid volunteers who donate blood for a community supply. In poorer countries, established supplies are limited and donors usually give blood when family or friends need a transfusion (directed donation). Many donors donate as an act of charity, but in countries that allow paid donation some donors are paid, and in some cases there are incentives other than money such as paid time off from work. Donors can also have blood drawn for their own future use (autologous donation). Donating is relatively safe, but some donors have bruising where the needle is inserted or may feel faint.

Blood DonationPotential donors are evaluated for anything that might make their blood unsafe to use. The screening includes testing for diseases that can be transmitted by a blood transfusion, including HIV and viral hepatitis. The donor must also answer questions about medical history and take a short physical examination to make sure the donation is not hazardous to his or her health. How often a donor can give varies from days to months based on what he or she donates and the laws of the country where the donation takes place. For example, in the United States, donors must wait eight weeks (56 days) between whole blood donations but only seven days between platelet pheresis donations.

The amount of blood drawn and the methods vary. The collection can be done manually or with automated equipment that only takes specific portions of the blood. Most of the components of blood used for transfusions have a short shelf life, and maintaining a constant supply is a persistent problem. This has led to some increased interest in autotransfusion, whereby a patient’s blood is salvaged during surgery for continuous reinfusion — or alternatively, is “self-donated” prior to when it will be needed. (Generally, the notion of “donation” does not refer to giving to one’s self, though in this context it has become somewhat acceptably idiomatic.)

Types of donation

Blood banks sometimes use a modified bus or similar large vehicle to provide mobile facilities for donation.

Blood donations are divided into groups based on who will receive the collected blood. An ‘allogeneic’ (also called ‘homologous’) donation is when a donor gives blood for storage at a blood bank for transfusion to an unknown recipient. A ‘directed’ donation is when a person, often a family member, donates blood for transfusion to a specific individual. Directed donations are relatively rare when an established supply exists. A ‘replacement donor’ donation is a hybrid of the two and is common in developing countries such as Ghana. In this case, a friend or family member of the recipient donates blood to replace the stored blood used in a transfusion, ensuring a consistent supply. When a person has blood stored that will be transfused back to the donor at a later date, usually after surgery, that is called an ‘autologous’ donation. Blood that is used to make medications can be made from allogeneic donations or from donations exclusively used for manufacturing.

Blood is sometimes collected using similar methods for therapeutic phlebotomy, similar to the ancient practice of bloodletting, which is used to treat conditions such as hereditary hemochromatosis or polycythemia vera. This blood is sometimes treated as a blood donation, but may be immediately discarded if it cannot be used for transfusion or further manufacturing.

The actual process varies according to the laws of the country, and recommendations to donors vary according to the collecting organization. The World Health Organization gives recommendations for blood donation policies, but in developing countries many of these are not followed. For example, the recommended testing requires laboratory facilities, trained staff, and specialized reagents, all of which may not be available or too expensive in developing countries.

An event where donors come to donate allogeneic blood is sometimes called a ‘blood drive’ or a ‘blood donor session’. These can occur at a blood bank, but they are often set up at a location in the community such as a shopping center, workplace, school, or house of worship.


Donors are typically required to give consent for the process and this requirement means minors cannot donate without permission from a parent or guardian. In some countries, answers are associated with the donor’s blood, but not name, to provide anonymity; in others, such as the United States, names are kept to create lists of ineligible donors. If a potential donor does not meet these criteria, they are ‘deferred’. This term is used because many donors who are ineligible may be allowed to donate later. Blood banks in the United States may be required to label the blood if it is from a therapeutic donor, so some do not accept donations from donors with any blood disease. Others, such as the Australian Red Cross Blood Service, accept blood from donors with hemochromatosis. It is a genetic disorder that does not affect the safety of the blood.

The donor’s race or ethnic background is sometimes important since certain blood types, especially rare ones, are more common in certain ethnic groups. Historically, donors were segregated or excluded on race, religion, or ethnicity, but this is no longer a standard practice.